Development and look for extended release formulations of isosorbide mononitrate according to osmotic. Controlled porosity osmotic pumpbased controlled release system of pseudoephedrinei cellulose acetate as being a semipermeable membrane. The present invention relates to controlled porous osmotic pump tablets of high permeable drugs and the preparation process thereof. Osmotic drug delivery uses the osmotic pressure for controlled delivery of drugs by using osmogens for upto 10 16 hrs. Formulation and evaluation of oral controlled release osmotic. Porosity and pore area determination of hollow fiber.
The measurement of osmotic pressure and its application to a study of aqueous phenol solutions by. There is achance of dose dumping if the coating process is not well controlled. Sandhya1, 2, 1hameeda zareen durani, zaara majeed1, y. July september 9 the unique feature of semipermeable membrane utilized for an osmotic pump is that it permits. Development of ethylcellulose coating on osmotic pump tablets.
The aim of the current study was to design a controlled porosity osmotic pump cpopbased drug delivery system for controlled release of an nsaid agent, ketorolac tromethamine, which is expected to improve patient compliance due to reduced frequency. Preparation of controlled porosity osmotic pump tablets for salvianolic acid and optimization of the formulation using an artificial neural. Review on controlled porosity osmotic pump tablets and its. Recent patent in controlled porosity osmotic pump request pdf. Osmotic drug delivery has come a long way since australian physiologists rose and nelson developed an implantable pump in 1955. Hence osmotic drug delivery technique is most interesting and widely acceptable among all other techniques. Formulation and invitro evaluation of controlled porosity osmotic pump release tablets of nifedipine zaara majeed, maddali sai meghana, sumera, ayesha parveen, sara zafar. It contains an additional component called flow moderator is inserted into the body of the osmotic pump after filling. The effect of matric and osmotic potential of soil on phytophthora root disease of persea indica. The porosity, pore size and pore size distribution of the membranes can be. Then, controlled porosity osmotic pump cpop tablet of gliclazide was designed to deliver drug in a controlled manner up to 16 h. The standard apparatus includes a plug sized core cell, a vacuum pump, hand operated pressure pump 2,000 psi output, a saturant vacuum tank and necessary hand operated valves and plumbing.
Preparation of controlled porosity osmotic pump tablets. Controlled porosity osmotic pump tablets thesis writing. Development and evaluation of controlled porosity osmotic. Apr 11, 2011 a system that can deliver multidrug at a prolonged rate is very important for the treatment of various chronic diseases such as diabetes, asthma and heart disease. Conclusion a porous osmotic pumpbased drug delivery system can. Rezaei dashtarzhandi, cmehdi abbasgholipourghadim, ashahab khademi afaculty of mechanical engineering, badvanced membrane technology research centre universiti. The study of membrane morphology generally is related to the properties of membrane surface 4. The effect of matric and osmotic potential of soil r. Optimization and development of swellable controlled. A boxbehnken experimental design was applied to optimize the parameters for cpop. Subcutaneous angiotensin ii infusion using osmotic pumps.
Asian journal of research in chemistry and pharmaceutical sciences. In the present study, attempts were made to develop and evaluate the controlled porosity osmotic pump cpop based drug delivery system of sparingly water soluble drug. Controlled porosity osmotic pump download pdf info publication number ep0309051b1. Then, controlled porosity osmotic pump cpop tablet of gliclazide was designed to. Various methods have been developped and are used each with advantages and drawbacks. An ideal zeroorder release system bhardwaj, peeyush on. Formulation and in vitro evaluation of sustained release tablets of venlafaxine hydrochloride by porous osmotic technology pamu. The controlled porosity osmotic pump has been developed via incorporation of leachable watersoluble small molecules, such as sodium chloride, potassium chloride, urea, and sucrose etc. Formulation and optimization of controlled porosity osmotic. Porosity and pore area determination of hollow fiber membrane incorporating digital image processing amohammad abbasgholipourghadim,amusa mailah, aintan zaurah mat darus, ba. Formulation and evaluation of osmotic pump delivery of. Captopril, osmotic tablets, controlled release design and development of controlled porosity osmotic tablets of captopril article history. Optimization and development of swellable controlled porosity. Enhancement of dissolution of glipizide from controlled porosity osmotic pump using a wicking agent and a solubilizing agent mahalaxmi.
One application of this is removing liquid flooding water from channels and gas diffusion layers and direct hydration of the proton exchange membrane in the membrane electrode assembly mea of the proton exchange membrane fuel cells. The cpop was prepared by the coating of polymers eudragit rspo and rlpo on a directly compressed core tablet. Preparation of controlled porosity osmotic pump tablets for. Formulation and evaluation of losartan potassium osmotic. Chitosanbased controlled porosity osmotic pump for colonspecific delivery system. Osmotic drug delivery devices based on osmotic drug delivery devices10,11 design and the state of use osmotic drug delivery system can be classi. Controlled porosity osmotic tablet of carvedilol phosphate prepared and evaluated in this study. Formulation and in vitro evaluation of sustained release. Ebscohost serves thousands of libraries with premium essays, articles and other content including controlled porosity osmotic pump tabletsan overview. This finding confirms that the mechanism of drug release is by the osmotic pressure. Google has not performed a legal analysis and makes no representation as. Controlled porosity solubility modulated osmotic pump tablets.
A controlled porosity osmotic pump cpop delivery system for sodium ferulate was prepared with cellulose acetate ca as semipermeable membrane, polyethyleneglycol 400 peg 400 as channeling. The coating composition of cpop includes pore forming. If you continue browsing the site, you agree to the use of cookies on this website. Enhancement of dissolution of glipizide from controlled porosity osmotic pump using a wicking agent and a solubilizing agent.
Enhancement of dissolution of glipizide from controlled. Water moves from high to low water activity due to osmosis and, if allowed, would equalize the water activity on both. The influence of the matric and osmotic potential of soil on the root system of p. A a core which comprises a therapeutically effective amount of diltiazem lmalate and an effective buffering amount of sodium bitartrate surrounded by b a rate controlling water insoluble wall, having a fluid permeability of 6. Alzet pumps deliver by the process of osmotic displacement. The controlledporosity osmotic pump has been developed via incorporation of leachable watersoluble small molecules, such as sodium chloride, potassium chloride, urea, and sucrose etc. Since fluid in pore spaces that are not interconnected can not be produced from a well, the saturations are more meaningful if expressed on the basis of effective porosity. Formulation and evaluation of oral controlled porosity osmotic pump tablet of methylphenidate hcl. The porous osmotic pump based drug delivery system for excellent controlled release of drug for 24 hrs. Formulation and evaluation of oral controlled release. Membrane surface porosity and pore area distribution. Ganesh kumar3 1 department of pharmaceutics, shadan womens college of pharmacy, hyderabad, 500004, andhra pradesh, india. Subcutaneous angiotensin ii infusion using osmotic pumps induces aortic aneurysms in mice hong lu 1, deborah a.
Formulation and optimization of controlled porosity. Also, the preparation of swellable controlled porosity osmotic pump tablet was facilitated by coating the core tablet with pore forming agent, thus eliminating the need for the more expensive laser drilling. If you have a different image of similar quality, be sure to upload it using the proper free license tag, add it to a relevant. Development and evaluation of a oncedaily controlled. The aim of the present investigation is to design and development of controlled release formulation of captopril based on osmotic technology to increase the resident time in order to improve the therapeutic effect of the drug by increasing its bioavailability. Chitosanbased controlled porosity osmotic pump for colon. Formulation and evaluation of controlled porosity osmotic pump for oral delivery of ketorolac article pdf available december 2012 with 383 reads how we measure reads. Pdf a novel controlled porosity osmotic pump system for. Subcutaneous angiotensin ii infusion using osmotic pumps induces aortic aneurysms in mice.
Ebscohost serves thousands of libraries with premium essays, articles and other content including controlledporosity osmotic pump tabletsan overview. Asian journal of pharmaceutics octdec 2016 10 4 287 formulation and optimization of controlled porosity osmotic pump tablet for oral administration of glipizide s. So it is difficult to formulate osmotic tablet of carvedilol phosphate which gives drug release up to 24 hr at zero. Controlled porosity osmotic pump tablet cpop system was designed to deliver nifedipine. This video shows the parts of the pump and describes how the pump operates to enable continuous delivery osmotic pump mechanism on vimeo. It is composed of three concentric layers the drug reservoir,the osmotic sleeve and the rate controlling semipermeable membrane. European patent office prior art keywords osmotic pump diltiazem malate wall core prior art date 19870924 legal status the legal status is an assumption and is not a legal conclusion.
Development and evaluation of controlled porosity osmotic pump for nifedipine and metoprolol combination. Video articles in jove about mini osmotic pump include spectral confocal imaging of fluorescently tagged nicotinic receptors in knockin mice with chronic nicotine administration, construction and implantation of a microinfusion system for sustained delivery of neuroactive agents. Disouza3 1department of pharmaceutics, sant gajanan maharaj college of pharmacy, mahagaon, gadhinglaj. Dec 17, 2015 the present study aimed to prepare, optimize, and evaluate tapentadol hydrochloride controlled porosity osmotic pump cpop and to achieve the drug release at nearly zeroorder.
Swellable, controlled porosity, osmotic pump tablet, taguchi orthogonal design, fraction. Effective porosity measured on core samples which are dried in a humidity oven so that clays retain one or two. The present study was aimed to develop osmotic controlled extended release formulations of losartan potassium an angiotensin. Osmotic pressure is the hydrostatic pressure produced by a. Asian journal of research in chemistry and pharmaceutical. Absolute and effective porosity of petroleum reservoirs. The goal of the present study ended up being design a controlled porosity osmotic pump cpopbased drug delivery system for controlled relieve an nsaid agent, ketorolac tromethamine, which will most likely improve patient compliance because of reduced frequency in addition, it eliminates the advantages of complicated and pricey laser drilling.
Nov 06, 1990 the instant invention is directed to an osmotic pump comprising. Studied a controlled porosity osmotic pump based drug delivery system. A porous osmotic pumpbased drug delivery system can be designed for controlled release of highly watersoluble drug oxybutynin. When pure liquid water is separated by a membrane, permeable to water but not solute, from a solution containing a nonvolatile solute, water will pass from the pure water side until sufficient extra pressure.
Objectives develop an ethylcellulose ecbased coating formulation for glipizide. Design and development of controlled porosity osmotic. Osmotically controlled oral drug delivery systems utilize osmotic pressure as energy source for the controlled delivery of drugs, independent of ph and hydrodynamic conditions of gastro intestinal tract git. Formulation and evaluation of osmotic pump delivery of oxybutynin. Development of ethylcellulose coating on osmotic pump tablets sophie zhai, 1 robert schmitt, 2 jennifer lhotegaston 3 1 the dow chemical company, shanghai, china 2 the dow chemical company, bound brook, nj, usa 3 the dow chemical company, midland, mi, usa. In this paper controlled porosity osmotic pump tablets cpopt for salvianolic acid sa were prepared and optimized with experimental design methods including an artificial neutral network ann method. Drug release from the developed formulations was independent of ph and agitational intensity and was dependent on. Ganesh kumar3 1 department of pharmaceutics, shadan womens college of. The weight of water collected from the sample is calculated from the volume of water by the relationship. Development of ethylcellulose coating on osmotic pump. The prototype solubilization method combined with controlled porosity osmotic pump based technique could provide a unique way to increase dissolution rate and bioavailability of many poorly water. The controlled porosity osmotic pump tablets do not need to be drilled by laser, but provides controlled porosity for drug release by adding a suitable quantity of poreforming agents into the semipermeable membrane. Solid dispersion sd of glz consisted of hydroxypropyl cellulose hpcssl as a polymeric solubilizer was manufactured by hot melt extrusion hme technology. The porous osmotic pump contains pore forming water soluble additives in the coating.
The instant invention is directed to an osmotic pump, for the controlled release of diltiazem lmalate to an environment of use, said pump comprising. Screening of formulation variables and in vitro investigation. So it is difficult to formulate osmotic tablet of carvedilol phosphate which gives drug release up to 24 hr at zero order. Jul 31, 2015 porosity by saturation method report slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Formulation and invitro evaluation of controlled porosity. In the present investigation, controlled porosity osmotic pump cpop system of glipizide gz was developed since preparation of cpop is simple. Controlled porosity osmotic tablet, zero order, poly ethylene glycol 400, mannitol. Received 25 aug 20 accepted 10 sept 20 available online sept 20 as dose, absorption rate constant, elimination rate constant, metabolic properties. Ep2085078a1 controlled porosity osmotic pump tablet of. Formulation and evaluation of controlled porosity osmotic. Studied a controlled porosity osmotic pumpbased drug delivery system. Drug release from the developed formulations was independent of ph and agitational intensity and was dependent on osmotic pressure of the release media. Controlled porosity solubility modulated osmotic pump.
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